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The uptake and intratumoral (intracrine) conversion of circulating adrenal androgens such as dehydroepiandrosterone sulfate (DHEA-S) to steroids capable of activating the wild type AR is a recognized driver of castration resistant prostate cancer (CRPC). SARMs and oral anabolic steroids have nearly the same side-effect profile, causing things such as the rapid breakdown of levels of high-density lipoprotein cholesterol (HDL, the. Anabolic or androgenic steroids usually have a 1:1 anabolic to androgenic ratio which means with every benefit there is a flaw involved. In the fetus, DHT and testosterone induce genital tubercle transformation into male external genitalia. DHT can be topically applied in a transdermal cream, but is not to be confused with testosterone cream or testogel/androgel. Oral Steroids. 3 Anavar. Some American adults order legal hormone prescriptions from US-based online services. 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